The Serbian athlete (28) and Manchester United midfielder (31) have been dating since 2014 and exchanged vows at Venice City Hall on Tuesday, just two days after the Euro 2016 championship ended.
The bride opted for a bohemian style off-white dress with ruffles, while the groom went similarly understated in a navy suit.
It's not yet known where they're celebrating their reception as they have been famously tight-lipped about details of their big day and shunned a big money magazine deal in favour of posing for a few photographers outside the church.
The newlyweds beamed as they left the ceremony by boat.
Ana, a former French Open champion, and her other half kept the details of their ceremony under lock and key, reportedly telling guests what time to arrive at Munich airport.
They wed in the same spot as George and Amal Clooney did two years ago.