Julie Baum and Tom Sylvester, who have been together for 11 years, will be married at the Rothera Research Station, on Adelaide Island to the west of the Antarctic Peninsula.
They will be joined by 20 fellow researchers as they embark on a two-day celebration, beginning with a champagne breakfast.
The couple will not be holding out for good weather though, with temperatures well below freezing and very little daylight.
Julie, who is making her wedding dress, said: "Over the last 10 years Tom and I have been working and travelling around the world. Getting married in Antarctica feels like it was meant to be.
"There is no better place really, I love snowy mountains and spending time in amazing places with awesome people."
The ceremony will take place at the weekend and will be performed by Rothera Research Station Leader and a BAT Magistrate Paul Samways.
Tom said: "Antarctica is an incredibly beautiful place and we have made such great friends here, so the setting couldn't be better.
"We have always wanted to have a small personal wedding, but never imagined we'd be able to get married in one of the most remote places on Earth."
The pair are experienced mountaineers and were selected to join the British Antarctic Survey in 2016 to manage deep-field science expeditions.
The marriage will be registered with the BAT Government and will be valid in the UK.